Oncotarget: триптолид-индуцированный апоптоз при немелкоклеточном раке легкого

Oncotarget недавно опубликовал « Триптолид-индуцированный апоптоз немелкоклеточного рака легкого с помощью нового пути, опосредованного miR204-5p / Caveolin-1 / Akt », в котором сообщается, что рак легкого является одним из наиболее распространенных злокачественных новообразований немелкоклеточного легкого во всем мире. рак составляет почти 80% всех случаев. К сожалению, многие пациенты с раком легких диагностируются на поздних стадиях болезни с плохим прогнозом. Авторы демонстрируют, что обработка триптолидом клеток NSCLC A549 и H460 снижает экспрессию мРНК / белка Caveolin -1, что приводит к активации Akt / Bcl-2-опосредованного пути митохондриального апоптоза. В целом, их результаты свидетельствуют о новом механизме, с помощью которого TL оказывает цитотоксическое действие на NSCLC через подавление CAV-1. Кроме того, результаты автора Oncotarget демонстрируют ключевую роль индукции TL пути Akt / Bax в апоптозе рака легких человека.

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