Онко-мишень: TAF15 способствует индуцируемой радиацией стрессовой реакции при раке.

Oncotarget недавно опубликовал « ETAF15 способствует индуцируемой радиацией стрессовой реакции при раке », в которой сообщалось, что TAF15 подавляется генетически, что привело к значительному снижению пролиферации клеток NSCLC. Клетки, лишенные TAF15, демонстрируют остановку клеточного цикла и усиление апоптоза за счет активации и накопления p53. В сочетании с облучением нокдаун TAF15 приводил к значительному снижению выживающей фракции клеточных линий NSCLC. Чтобы определить важность поверхностной экспрессии TAF15, они нацелены на TAF15 с помощью антитела. В сочетании с облучением антитело против TAF15 привело к уменьшению выживающей фракции раковых клеток. Эти исследования Oncotarget показывают, что TAF15 является индуцируемой излучением молекулярной мишенью, доступной для противораковых антител и повышающей жизнеспособность клеток в ответ на излучение.

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