clinics in us

Доктор Джонатан А. Келбер из Калифорнийского государственного университета в Нортридже сказал: « Секвенирование следующего поколения (NGS), такое как РНК-секвенирование или анализ всего генома, опухолевой ткани, полученной от пациентов, в сочетании с современной биоинформатикой обладает большим потенциалом для улучшения исходов заболевания за счет выявления новых биомаркеров начала, прогрессирования и устойчивости к терапии ». Среди преимуществ NGS перед другими технологиями - возможность выполнять мониторинг транскриптома с высоким разрешением для выявления вариаций изоформ, аномальных паттернов экспрессии и сигнатур экспрессии генов с низкой экспрессией или длинных некодирующих РНК. Однако понимание влияния микроокружения опухоли на экспрессию генов и, в частности, профили биомаркеров раковых клеток затруднено тем фактом, что исследователи имеют ограниченный доступ к свежей опухолевой ткани, содержащей качественный и легко доступный материал нуклеиновых кислот - эти образцы обычно не берутся в больницах из-за логистических проблем, связанных со сбором, обработкой и хранением свежезамороженных тканей .

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clinics in us

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